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KMID : 0357319800150010063
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Journal of the Korean Society for Microbiology
1980 Volume.15 No. 1 p.63 ~ p.69
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Effect of Corynebacterium parvum on Immune Response to Sheep Red Blood Cells
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吳鐘鉉/Oh, Jung-Hyun
李憲九/河大有/Lee, Hern-Ku/Ha, Tai-You
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Abstract
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The effects of intravenous administration of C. parvum on immune response to sheep red blood cells in mice were investigated. Significant delayed type hypersensitivity depression occurred when C parvum was given intravenously before antigen sensitization.
The depressed effect of C. parvum was completely abolished by treatment of cyclophosphamide. However, delayed type hypersensitivity was not depressed when C. parvum given after antigen.
This depression is considered to be attributable to the generation of suppressor cells which were either suppressor T cell or C. parvum activated macrophage, because C. parvum inhibited the proliferation of S. typhimurium in vivo and also induced splenomegaly and hepatomegaly, known as manifestation of macrophage activation.
Serum antibody titers were not significantly affected by C. parvum regardless of time of C. parvunt administration.
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